C5Research Involvement



Cardiovascular Outcomes

.

VISTA-16
Varespladib
sPLA2 inhibitor
2014
dal – Outcomes
Dalcetrapib
CETP inhibitor
2012
TRACER
Vorapaxar (PAR-1)
Thrombin-Receptor Antagonist
2012
CRESCENDO
Rimonabant
Cannabanoid Receptor Antagonist
2010
PPAR
Rosiglitazone
PPAR Agent
2007
CAMELOT
Amlodipine (Novasc®)
Anti-Hypertensive
2004
GUSTO IV - ACS
Abcixmab (ReoPro®)
GP IIb/IIIa Inhibitor
2001


Antiplatelet

GP IIB/IIIa Inhibitors

CHARISMA
Clopiogrel (Plavix®)
GP IIb/IIIa Ihibitor
2006
FINESSE
Abcixmab (ReoPro®)
GP IIb/IIIa Inhibitor
2008
CREDO
Clopiogrel (Plavix®)
GP IIb/IIIa Ihibitor
2002
SYMPHONY
Sibrafiban
GP IIb/IIIa Inhibitor
2000
GUSTO V
Abcixmab (ReoPro®)
GP IIb/IIIa Inhibitor
2002
EPIC
Eptifibatide (Integrilin®)
GP IIb/IIIa Inhibitor
1994


Thrombin Inhibition

 

CHOOSE
Bivalirudin (Angiomax®)
Direct Thrombin Inhibitor
2014
REPLACE-2
Bivalirudin (Angiomax®)
Direct Thrombin Inhibitor
2006
EVOLUTION-ON
Bivalirudin (Angiomax®)
Direct Thrombin Inhibitor
2006
EVOLUTION-OFF
Bivalirudin (Angiomax®)
Direct Thrombin Inhibitor
2006
CACHET
Bivalirudin (Angiomax®)
Direct Thrombin Inhibitor
2002

Atherosclerosis Progression

AQUARIUS
Aliskerin
Anti-hypertensive
2003
SATURN
Rosuvastatin (Crestor®)
Statin
2011
PERISCOPE
Pioglitazone (ACTOS®)
TZD
2008
STRADIVARIUS
Rimonabant
Cannabanoid Receptor Antagoist
2008
ILLUSTRATE
Torcetrapib
CETP Inhibitor
2007
ASTEROID
Rosuvastatin (Crestor®)
Statin
2006
ACTIVATE
CS-505
ACAT Inhibitor
2006
REVERSAL
Atorvastatin (Lipitor®)
Statin
2005
NORMALISE
Amlodipine (Novasc®)
Calcium Channel Blocker
2004
ApoA1 Milano
ETC-216
ApoA1 protein
2003

Diabetes

STAMPEDE
Bariatric Surgery
Surgical Therapy
2012

Heart Failure

Ascend HF
Nesiritide
Recombinant BNP
2011

Heart Transplantation

TICTAC
Tacrolimus and MMF
Immunosuppression
2011
RADB253
Evirolimus
Immunosuppression
2003